Anesthesia providers play a critical role in the gap between unmet surgical need and access to safe surgical care. Providers from high-income countries can help fill this gap, particularly during crises, but it is critical to provide care responsibly and ethically. Most unmet surgical need is in low-income and middle-income countries where limited infrastructural, human, and material resources pose significant challenges. Anesthesia providers must recognize these difficulties as they apply to the local context and plan accordingly. This article outlines some of the unique issues and provides a framework of considerations for safe and responsible anesthesia delivery in resource-limited areas.