Prevalence and Mortality of Triple-Negative Breast Cancer in West Africa: Biologic and Sociocultural Factors

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Prevalence and Mortality of Triple-Negative Breast Cancer in West Africa: Biologic and Sociocultural Factors


JournalJCO Global Oncology
Article typeJournal research article – Clinical research
Publication date – Jul – 2021
Authors – Gift C. Nwagu , Shristi Bhattarai , Monica Swahn, Saad Ahmed , Ritu Aneja
Keywordscancer-burdened women, Triple-negative breast cancer (TNBC), West Africa
Open access – Yes
SpecialityGeneral surgery, Surgical oncology
World region Western Africa

Language – English
Submitted to the One Surgery Index on July 30, 2021 at 2:52 am
Abstract:

Key Objective
Triple-negative breast cancer (TNBC) is a malignant breast cancer, lacking targeted therapy, which would benefit from further research to understand its nature and the observed variation in its malignancy between women of differing ancestries. This large-scale systematic literature review examines the current and emerging biologic and nonbiologic factors, which have been shown to influence TNBC disease outcomes among indigenous West African (WA) females while discussing some prospective steps that could be adopted by health care systems for the reduction of this burden.

Knowledge Generated
WA women are the most burdened populations in relation to TNBC. Biologic and economic factors have been shown to significantly influence the TNBC disease outcomes. Women’s education initiatives, specialist training, and accessible health care are needed in WA countries.

Relevance
The determination of WA-specific biologic, cultural, and socioeconomic TNBC factors could align efforts in developing treatment options and physician recommendations to cancer-burdened women.

OSI Number – 21182

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