Management guidelines of penile cancer- a contemporary review of sub-Saharan Africa

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Management guidelines of penile cancer- a contemporary review of sub-Saharan Africa

JournalInfectious Agents and Cancer
Publication date – May – 2020
Authors – Ayun Cassell, Bashir Yunusa, Burgess Manobah, and Desire Wambo
KeywordsHuman papilloma virus, Penectomy, Penile Cancer, Sub-Saharan Africa
Open access – Yes
SpecialitySurgical oncology, Urology surgery
World region Central Africa, Eastern Africa, Middle Africa, Southern Africa, Western Africa

Language – English
Submitted to the One Surgery Index on May 31, 2020 at 2:39 pm
Abstract:

Background
Penile cancer is a rare malignancy with prevalence higher in areas of high Human Papilloma Virus (HPV) such as Africa, Asia and South America. In middle- and low-income countries where circumcision is not routinely practiced, the rate of penile cancer could be ten times higher.

Main body of the abstract
A literature review was conducted from 1992 to 2019 using PubMed, Google Scholar, African Journal Online and Google with inclusion of 27 publications with emphasis on the Sub-Saharan literature. Findings revealed that most men with penile cancer in Sub-Saharan Africa (SSA) present with locally advanced to advanced disease with devastating consequences. The option of penile sparing procedure is reduced with most treatment option directed to mutilating surgeries. The lack of appropriate chemotherapy and radiotherapy worsens the prognosis in the region.

Short conclusion
Human Papilloma Virus (HPV) vaccination may not be cost-effective for most regions in SSA. Therefore, early childhood circumcision might be the best advocated alternative for prevention.

OSI Number – 20461
PMID – 7195778

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