Journal – Medicine Access At Point of Care
Article type – Journal research article – Clinical research
Publication date – Dec – 2021
Authors – Roland Nnaemeka Okoro, Kasim Abdullahi, Dauda Ayuba Dayar
Keywords – Gastric acid–related diseases, guideline-recommended, inappropriate prescription, Nigeria, proton-pump inhibitor
Open access – Yes
Speciality – General surgery, Other
World region Western Africa
Country: Nigeria
Language – English
Submitted to the One Surgery Index on December 14, 2021 at 7:02 am
Abstract:

Background:
Proton-pump inhibitor (PPI) is a widely used medication class globally. Because of its good safety profile, there is a huge likelihood of inappropriate use.

Objectives:
To determine the prevalence of PPI use and indications, describe its pattern of usage, and identify factors associated with inappropriate prescriptions at a federal tertiary teaching hospital in Maiduguri, Nigeria.

Methods:
PPI prescriptions were retrospectively assessed in the General Outpatients’ Department (GOPD) and Gastroenterology Unit (GITU) of a teaching hospital. Relevant data for the study were extracted from the patients’ medical records. Chi-square or Fisher’s exact tests where appropriate were used to identify factors associated with inappropriate PPI prescriptions. A p < 0.05 was considered to be significant.

Results:
PPIs were prescribed to 73.3% (220/300) of patients, while inappropriate prescriptions were noted in 91.4% (201/220) of these patients. Epigastric pain (49.5%) was the most common PPI indication, while omeprazole was the highest prescribed (53.4%). Nearly all inpatients (98.2%), those with epigastric pain (95.7%), and patients who were prescribed intravenous PPIs had more inappropriate PPI prescriptions compared to others.

Conclusion:
This study revealed a high prevalence of PPI use and inappropriate prescriptions at the study hospital. As a result, these findings highlight the importance PPI-based stewardship program at the study hospital.

OSI Number – 21393

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